Grooming behavior

Across TCGA patient cohorts, RNA activity of the Grooming behavior pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12_S1395, HMGCL, and RBM47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Grooming behavior activity versus AKAP12_S1395 in PDAC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AKAP12_S1395 →	-0.727	-0.045	.001	.008	3	5
GBM	HMGCL →	+0.265	+0.057	.001	<.001	3	5
GBM	RBM47 →	+0.412	+0.064	.004	.001	3	5
HNSC	SVIL_S549 →	-0.822	-0.077	<.001	<.001	3	5
HNSC	SYNPO2_Y622 →	-0.602	-0.078	.001	<.001	3	5
HNSC	CACNA2D1 →	-0.576	-0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007625 vs AKAP12_S1395 — PDAC

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