Excretion

Across TCGA cell cohorts, RNA activity of the Excretion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF141, LRRC46, and GDF9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF141 grouped by Excretion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF141 →	-1.815	-1.205	.005	.004	3	5
LARGE_INTESTINE	LRRC46 →	-0.449	-0.891	.005	.005	3	4
SOFT_TISSUE	GDF9 →	-0.207	-1.327	.008	<.001	3	3
SOFT_TISSUE	ZNF24 →	-1.014	-1.143	.004	.001	3	3
SKIN	F8A3 →	-1.330	-0.743	.009	.004	3	3
LIVER	ZNRF2 →	+0.822	+0.960	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF141 by Excretion activity — SOFT_TISSUE

Explore this box plot interactively →