Q-omics provides the consensus-scored F8A3 profile across patient tissues and cancer cell-line models. F8A3 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, F8A3 is differentially expressed in 10, with the highest sampling consensus in STAD. Additionally, F8A3 RNA expression shows 5,216 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRC, STAD, and BRCA as cancer lineages where F8A3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for F8A3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes F8A3 survival associations across molecular data types. F8A3 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible F8A3 RNA expression–survival associations across cancer types. High F8A3 expression shows unfavorable associations in KIRC, COAD, ACC, KIRP and READ, but favorable associations in MESO. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for F8A3 RNA expression.
This table summarizes F8A3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for F8A3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. F8A3 shows lower tumor expression in THCA and higher tumor expression in STAD, HNSC, BLCA, LIHC and KIRC. The STAD box plot shows higher F8A3 RNA expression in tumor versus normal tissue (log2 FC = +0.341, t-test p < 0.001).
This table shows molecular features associated with F8A3 in patient tissues and cancer cell lines. In patient samples, F8A3 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, F8A3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BONE.
