Mesodermal cell fate specification

Across TCGA patient cohorts, RNA activity of the Mesodermal cell fate specification pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NHLRC2, RDH10, and SLC9A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesodermal cell fate specification activity versus NHLRC2 in UCEC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NHLRC2 →	+0.243	+0.126	.001	<.001	3	5
BRCA	RDH10 →	+0.860	+0.057	<.001	<.001	3	4
LSCC	SLC9A9 →	-0.376	-0.078	.005	<.001	3	4
HNSC	SPINT1 →	+0.465	+0.067	<.001	<.001	3	4
UCEC	XPNPEP1 →	+0.260	+0.103	<.001	<.001	3	4
LSCC	CARD11 →	-0.463	-0.062	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007501 vs NHLRC2 — UCEC

Explore this scatter interactively →