Mesoderm development

Across TCGA patient cohorts, RNA activity of the Mesoderm development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRMD6, LUZP1, and AHNAK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm development activity versus FRMD6 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FRMD6 →	+0.949	+0.814	<.001	<.001	3	5
LUAD	LUZP1 →	+0.384	+0.749	<.001	<.001	3	5
LSCC	AHNAK2 →	+1.154	+0.605	.003	.004	3	5
PDAC	RAB40C →	-0.225	-0.349	.002	.001	3	4
LUAD	LINC01094 →	+0.522	+0.572	<.001	.006	3	4
LSCC	PPFIBP1 →	+0.547	+0.651	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007498 vs FRMD6 — LSCC

Explore this scatter interactively →