Neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMAIP1, PLAUR, and IL32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast proliferation activity versus PMAIP1 in URINARY_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PMAIP1 →	+1.775	+0.194	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	PLAUR →	+2.608	+0.276	.001	<.001	3	5
PANCREAS	IL32 →	+4.117	+0.197	<.001	<.001	3	5
PANCREAS	FCF1 →	+0.777	+0.209	.002	.002	3	4
BLOOD_Leukemia	ZBTB2 →	+0.590	+0.210	.004	.004	2	5
URINARY_TRACT	DLG1 →	+0.794	+0.206	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007405 vs PMAIP1 — URINARY_TRACT

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