Female gamete generation

Across TCGA patient cohorts, RNA activity of the Female gamete generation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, TOP2A, and ZNF622_S143, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female gamete generation activity versus SMC4 in GBM (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.688	+0.046	<.001	<.001	3	8
UCEC	TOP2A →	+1.160	+0.051	<.001	<.001	3	8
LUAD	ZNF622_S143 →	+0.699	+0.034	<.001	<.001	3	8
BRCA	ESF1 →	+0.429	+0.021	<.001	.002	3	8
LUAD	ESF1_S153 →	+0.917	+0.044	<.001	<.001	3	8
LUAD	ANLN →	+1.056	+0.050	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007292 vs SMC4 — GBM

Explore this scatter interactively →