Sperm axoneme assembly

Across TCGA patient cohorts, RNA activity of the Sperm axoneme assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT122, LZTFL1, and BBS7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm axoneme assembly activity versus IFT122 in BRCA (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFT122 →	+0.313	+0.062	<.001	<.001	3	7
BRCA	LZTFL1 →	+0.520	+0.060	<.001	<.001	3	7
BRCA	BBS7 →	+0.410	+0.063	<.001	<.001	3	7
UCEC	WDR35 →	+0.489	+0.096	<.001	<.001	3	7
BRCA	IFT88 →	+0.362	+0.056	<.001	<.001	3	7
BRCA	RPGR_S961 →	+0.688	+0.073	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007288 vs IFT122 — BRCA

Explore this scatter interactively →