Sperm axoneme assembly

Across TCGA pan-cancer cohorts, RNA activity of the Sperm axoneme assembly pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 28 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Sperm axoneme assembly pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and UCEC, show the opposite pattern, with higher activity associated with better survival.

BRCA, LGG, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.944	0.816	<.001	54	view →
LGG	DFS	Median	All	0.651	0.803	<.001	49	view →
UCEC	OS	Tertile	All	0.966	0.892	.001	36	view →
BLCA	DFS	Tertile	II,III,IV	0.645	0.480	.011	26	view →
SCLC	DFS	Tertile	All	0.312	0.562	.016	25	view →
READ	OS	Tertile	II,III,IV	1.000	0.881	.011	15	view →
PAAD	OS	Median	All	0.546	0.278	.004	15	view →
THYM	DFS	Median	II,III,IV	1.000	0.849	.017	14	view →
ACC	DFS	Median	II,III,IV	0.699	0.350	.010	14	view →
KIRP	DFS	Median	II,III,IV	0.903	0.345	.013	14	view →
UCS	OS	Tertile	IV	1.000	0.303	.036	12	view →
KIRC	DFS	Median	III,IV	0.369	0.572	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0007288–BRCA (DFS)

Open the BRCA breakdown →