Sperm axoneme assembly

Across TCGA patient cohorts, RNA activity of the Sperm axoneme assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC3, PPP2CA, and HSPA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm axoneme assembly activity versus RAC3 in LSCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAC3 →	+0.944	+0.290	<.001	<.001	3	4
LUAD	PPP2CA →	+0.204	+0.184	.001	.004	3	4
LUAD	HSPA4 →	+0.268	+0.243	.002	.002	3	4
LSCC	BRCA1 →	+0.691	+0.230	<.001	.009	3	4
LSCC	SS18 →	+0.385	+0.246	.003	.004	3	4
LSCC	MEAF6 →	+0.263	+0.189	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007288 vs RAC3 — LSCC

Explore this scatter interactively →