Notch signaling pathway

Across TCGA cell cohorts, RNA activity of the Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K7CL, PRUNE1, and REL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K7CL grouped by Notch signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAP3K7CL →	-2.112	-1.324	.003	.005	3	4
URINARY_TRACT	PRUNE1 →	+1.328	+1.528	<.001	<.001	3	4
BREAST	REL →	+0.642	+0.644	.006	.007	3	4
BONE	RAB28 →	+0.960	+1.320	.002	.007	3	3
LUNG_NSCLC_LUSC	PERP →	+2.476	+1.427	<.001	<.001	3	3
LUNG_NSCLC_LUSC	TADA3 →	-1.228	-1.376	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K7CL by Notch signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →