G protein-coupled glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP13, ZBTB17, and HYI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP13 grouped by G protein-coupled glutamate receptor signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	USP13 →	+0.766	+0.531	.004	.002	3	3
BONE	ZBTB17 →	+0.933	+0.453	.009	.001	2	4
LUNG_SCLC	HYI →	+1.338	+0.429	.001	.001	3	3
BLOOD_Leukemia	HAUS4 →	-0.619	-1.079	<.001	.003	3	3
BREAST	MSH4 →	-0.127	-0.789	.003	<.001	3	3
BONE	NBPF11 →	+1.001	+0.428	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP13 by G protein-coupled glutamate receptor signaling pathway activity — OVARY

Explore this box plot interactively →