Glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKD3, CEBPD, and PSTPIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKD3 grouped by Glutamate receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRKD3 →	+1.117	+0.903	.002	.002	2	5
SOFT_TISSUE	CEBPD →	+0.921	+1.007	.001	.008	3	4
CNS	PSTPIP1 →	-0.866	-0.844	.007	.004	3	3
LIVER	MROH1 →	-1.116	-1.389	<.001	.004	3	3
SKIN	RRM2B →	-0.980	-0.875	.003	<.001	3	3
BREAST	C14orf28 →	-0.289	-0.501	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKD3 by Glutamate receptor signaling pathway activity — SKIN

Explore this box plot interactively →