Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB2, SLC8A1, and IL10RA, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activity versus ZEB2 in CHOL (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	ZEB2 →	+1.271	+0.036	<.001	<.001	3	26
SARC	SLC8A1 →	+1.122	+0.026	<.001	<.001	3	26
CHOL	IL10RA →	+2.119	+0.039	<.001	<.001	3	25
DLBC	GIMAP6 →	+1.317	+0.032	<.001	<.001	3	25
DLBC	PIK3R5 →	+1.541	+0.043	<.001	<.001	3	25
CHOL	MS4A7 →	+1.422	+0.035	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007193 vs ZEB2 — CHOL

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