Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 79 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and UCEC, show the opposite pattern, with higher activity associated with better survival.

UVM, MESO, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	1.000	0.216	.006	50	view →
MESO	OS	Tertile	II,III,IV	0.145	0.684	<.001	43	view →
READ	OS	Median	All	0.838	0.962	.002	31	view →
UCEC	DFS	Median	IV	0.864	0.541	.009	28	view →
LUSC	OS	Median	II,III,IV	0.676	0.803	.005	24	view →
LGG	OS	Quartile	All	0.931	0.808	<.001	24	view →
KICH	DFS	Median	All	0.682	0.945	.003	15	view →
SKCM	OS	Tertile	III,IV	0.662	0.336	.003	14	view →
CHOL	DFS	Median	All	0.648	0.258	.018	12	view →
KIRC	DFS	Median	All	0.569	0.707	.012	11	view →
GBM	DFS	Tertile	All	0.350	0.201	.010	9	view →
SCLC	OS	Quartile	IV	0.164	0.571	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0007193–UVM (DFS)

Open the UVM breakdown →