Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF8, TBC1D2B, and URB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activity versus PRPF8 in GBM (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF8 →	-0.216	-0.062	.002	<.001	3	9
OV	TBC1D2B →	+0.400	+0.044	<.001	<.001	3	8
OV	URB2 →	-0.227	-0.020	.005	.002	3	8
OV	ANTXR2 →	+0.535	+0.033	.002	.001	3	8
OV	PARP1 →	-0.511	-0.032	.002	.001	3	8
BRCA	RANBP2 →	-0.196	-0.022	.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007193 vs PRPF8 — GBM

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