Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, PDE1A, and RHOJ, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activity versus SRPX in UCEC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRPX →	+1.018	+1.284	.003	<.001	3	9
CCRCC	PDE1A →	+0.747	+0.878	<.001	<.001	3	9
OV	RHOJ →	+0.830	+0.930	<.001	<.001	3	9
HNSC	FGF7 →	+1.027	+0.737	.002	.002	3	9
OV	ABCA8 →	+1.161	+0.892	<.001	<.001	3	9
BRCA	JAM2 →	+0.684	+0.898	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007193 vs SRPX — UCEC

Explore this scatter interactively →