Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A5, HMGN1, and MBNL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL4A5 grouped by Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	COL4A5 →	-2.740	-0.257	.002	.001	3	4
LUNG_SCLC	HMGN1 →	+0.979	+0.265	<.001	<.001	3	3
LUNG_SCLC	MBNL3 →	+2.823	+0.257	.003	.003	3	3
BLOOD_Lymphoma	CLSTN3 →	-2.537	-0.444	.003	.005	3	3
LIVER	GATC →	+0.529	+0.254	.006	<.001	2	3
SOFT_TISSUE	EML3 →	-0.592	-0.764	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL4A5 by Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activity — LIVER

Explore this box plot interactively →