Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX60, H2AC17, and UQCC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway activity versus DDX60 in BLOOD_Lymphoma (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DDX60 →	+1.321	+0.196	.003	.008	2	7
OVARY	H2AC17 →	-1.055	-0.362	.004	.006	3	5
LUNG_NSCLC_LUSC	UQCC3 →	-0.947	-0.324	.006	.006	3	5
BLOOD_Lymphoma	NMI →	+1.706	+0.248	.004	.004	2	5
BLOOD_Lymphoma	FLNA →	+2.203	+0.300	.001	.002	3	4
BLOOD_Leukemia	PRKAG2 →	+0.867	+0.190	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007193 vs DDX60 — BLOOD_Lymphoma

Explore this scatter interactively →