Adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZMYND8, NUP205, and RCSD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus ZMYND8 in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZMYND8 →	-0.359	-0.044	<.001	<.001	3	10
GBM	NUP205 →	-0.206	-0.035	<.001	<.001	3	10
UCEC	RCSD1 →	+0.538	+0.044	.001	<.001	3	9
COAD	RCSD1_S351 →	+0.591	+0.022	<.001	<.001	3	9
UCEC	WIPF1 →	+0.396	+0.040	.003	.001	3	9
LSCC	DHX9 →	-0.249	-0.035	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007189 vs ZMYND8 — LSCC

Explore this scatter interactively →