Adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 156 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.386	0.914	.002	80	view →
MESO	OS	Quartile	II,III,IV	0.224	0.488	.005	53	view →
ACC	OS	Quartile	III,IV	0.247	0.872	.001	46	view →
KICH	OS	Median	III,IV	0.420	0.914	.006	40	view →
ESCA	DFS	Quartile	III,IV	0.651	0.234	.008	31	view →
SKCM	OS	Quartile	II,III,IV	0.606	0.140	.001	29	view →
SARC	OS	Median	All	0.930	0.739	.001	26	view →
LGG	OS	Median	All	0.850	0.925	<.001	20	view →
SCLC	DFS	Median	III,IV	0.242	0.525	.009	19	view →
LUAD	OS	Quartile	All	0.728	0.826	.009	17	view →
CHOL	OS	Median	II,III,IV	0.024	0.601	.025	15	view →
LUSC	OS	Tertile	IV	0.001	0.965	.045	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0007189–KIRP (DFS)

Open the KIRP breakdown →