Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-modulating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELK3, CAVIN3, and CAMK2D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway activity versus ELK3 in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELK3 →	+1.018	+0.248	.002	.005	3	6
OVARY	CAVIN3 →	+3.044	+0.271	<.001	.002	3	5
KIDNEY	CAMK2D →	+1.543	+0.357	.002	<.001	3	5
STOMACH	CMTM6 →	+1.194	+0.259	<.001	<.001	3	4
BLOOD_Lymphoma	DPYSL2 →	+1.471	+0.241	<.001	<.001	3	4
URINARY_TRACT	SNX7 →	+0.892	+0.326	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007188 vs ELK3 — BLOOD_Leukemia

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