Establishment of tissue polarity

Across TCGA patient cohorts, RNA activity of the Establishment of tissue polarity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT22, PTK7, and LRP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of tissue polarity activity versus IFT22 in COAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFT22 →	+0.390	+0.024	.004	.005	3	8
COAD	PTK7 →	+0.491	+0.030	<.001	<.001	3	8
OV	LRP1 →	+0.638	+0.047	<.001	<.001	3	8
BRCA	MAP1A →	+0.484	+0.035	<.001	<.001	3	8
OV	PRKCD →	-0.351	-0.031	<.001	<.001	3	7
LSCC	SEC11C →	-0.866	-0.035	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007164 vs IFT22 — COAD

Explore this scatter interactively →