Female meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Female meiotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, TUBB8, and ATP6V1B2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female meiotic nuclear division activity versus TOP2A in PANCREAS (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TOP2A →	+2.066	+0.292	.001	.004	3	12
SKIN	TUBB8 →	+1.300	+0.220	<.001	.006	3	9
OVARY	ATP6V1B2 →	-1.129	-0.250	.007	.003	2	9
LUNG_NSCLC_LUSC	GNS →	-1.463	-0.201	.004	<.001	3	7
BLOOD_Leukemia	SMC2 →	+0.770	+0.206	<.001	<.001	3	7
PANCREAS	DNTTIP2 →	+0.566	+0.239	.001	.008	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007143 vs TOP2A — PANCREAS

Explore this scatter interactively →