Male meiotic nuclear division

Across TCGA patient cohorts, RNA activity of the Male meiotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT3_S299, CSE1L, and LIG1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male meiotic nuclear division activity versus CNOT3_S299 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNOT3_S299 →	+0.937	+0.048	.002	.001	3	10
LSCC	CSE1L →	+0.345	+0.041	<.001	<.001	3	10
BRCA	LIG1 →	+0.434	+0.045	<.001	<.001	3	10
LSCC	MCM2 →	+0.621	+0.064	<.001	<.001	3	10
UCEC	NCAPD2 →	+0.599	+0.064	<.001	<.001	3	10
LSCC	FEN1 →	+0.483	+0.058	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007140 vs CNOT3_S299 — OV

Explore this scatter interactively →