Male meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Male meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP5D1, DNAH1, and GRPEL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP5D1 grouped by Male meiotic nuclear division-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PPP5D1 →	+0.406	+0.282	.001	.001	3	4
LUNG_SCLC	DNAH1 →	-0.675	-0.803	.009	.002	3	4
BREAST	GRPEL2 →	+0.582	+0.834	<.001	.001	3	4
BLOOD_Leukemia	BCAS2 →	+0.660	+1.155	.002	<.001	3	4
LIVER	WWP1 →	-0.701	-1.252	.005	.001	3	4
SKIN	HDAC3 →	+0.432	+0.754	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP5D1 by Male meiotic nuclear division activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →