Nuclear migration

Across TCGA patient cohorts, RNA activity of the Nuclear migration pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUN1, LMNA, and LMNA_S652, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration activity versus SUN1 in PDAC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SUN1 →	+0.536	+0.265	<.001	.001	3	4
OV	LMNA →	+0.493	+0.228	<.001	<.001	2	5
LUAD	LMNA_S652 →	+0.694	+0.139	<.001	<.001	3	4
LUAD	NAA25 →	-0.226	-0.143	<.001	<.001	3	4
LUAD	PLIN2 →	-0.903	-0.208	<.001	<.001	3	4
GBM	LMNB1_S23 →	+0.891	+0.333	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007097 vs SUN1 — PDAC

Explore this scatter interactively →