Spindle assembly involved in female meiosis

Across TCGA cell cohorts, RNA activity of the Spindle assembly involved in female meiosis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT122, ZNF268, and CCL15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT122 grouped by Spindle assembly involved in female meiosis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFT122 →	+0.178	+0.112	.002	.003	3	5
BREAST	ZNF268 →	-0.143	-0.112	.004	.006	3	4
LARGE_INTESTINE	CCL15 →	+0.210	+0.116	.004	.002	3	4
LUNG_SCLC	HS6ST1 →	-0.278	-0.130	.004	.001	3	4
STOMACH	MDH1B →	+0.120	+0.150	.003	<.001	3	4
STOMACH	DUSP21 →	+0.209	+0.122	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT122 by Spindle assembly involved in female meiosis activity — SOFT_TISSUE

Explore this box plot interactively →