Spindle assembly involved in female meiosis

pathway activity — tumor vs normal
GO:0007056Tumor vs NormalRNA activityBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, RNA activity of the Spindle assembly involved in female meiosis pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

LUAD, KIRC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log2 scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.
LineageGenderStageActivity changepSampling consensus
LUADMaleIII,IV+0.161<.00111view →
KIRCMaleIV+0.117<.00111view →
KIRPMaleIII,IV+0.094<.00111view →
LUSCFemaleII,III,IV+0.188<.0019view →
LIHCAllIII,IV+0.092<.0019view →
HNSCMaleIV+0.113<.0018view →
BLCAAllAll+0.089<.0018view →
STADFemaleAll+0.201<.0017view →
THCAAllIII,IV+0.056<.0017view →
UCECAllIII,IV+0.133<.0016view →
BRCAAllAll+0.125<.0016view →
KICHAllAll+0.055.0015view →
Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0007056–LUAD

Tumor-vs-normal pathway-activity box plot for Spindle assembly involved in female meiosis in LUAD.

Open the LUAD breakdown →

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