Cell-cell junction assembly

Across TCGA cell cohorts, RNA activity of the Cell-cell junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRF1, ELF4, and STING1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction assembly activity versus ADGRF1 in LUNG_NSCLC_LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADGRF1 →	+2.883	+0.205	.008	.006	3	6
BLOOD_Lymphoma	ELF4 →	+1.385	+0.256	.007	<.001	3	6
URINARY_TRACT	STING1 →	+2.085	+0.232	.001	.005	3	6
LUNG_NSCLC_LUAD	FGFBP1 →	+2.084	+0.302	<.001	<.001	3	6
BLOOD_Lymphoma	CMTM6 →	+1.342	+0.278	<.001	<.001	3	5
STOMACH	CXCL8 →	+3.582	+0.230	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007043 vs ADGRF1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →