Protein catabolic process in the vacuole

Across TCGA cell cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL27A, ROCK1, and TRMT1L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL27A grouped by Protein catabolic process in the vacuole-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RPL27A →	-0.306	-1.716	.001	.001	3	3
LARGE_INTESTINE	ROCK1 →	-0.169	-0.919	<.001	<.001	3	3
LUNG_NSCLC_LUAD	TRMT1L →	-0.147	-0.705	.008	.006	3	3
OESOPHAGUS	PIK3C2B →	-0.141	-1.200	.007	.005	3	3
LUNG_NSCLC_LUSC	SLC5A2 →	-0.166	-1.613	.003	.001	3	2
BLOOD_Lymphoma	PPP3CA →	+0.324	+1.442	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL27A by Protein catabolic process in the vacuole activity — BLOOD_Lymphoma

Explore this box plot interactively →