Protein catabolic process in the vacuole

Across TCGA pan-cancer cohorts, RNA activity of the Protein catabolic process in the vacuole pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Protein catabolic process in the vacuole pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, LUAD, and TGCT are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.781	0.404	.003	38	view →
LUAD	DFS	Median	III,IV	0.729	0.403	.009	19	view →
TGCT	DFS	Tertile	All	0.977	0.701	<.001	18	view →
KIRC	DFS	Tertile	IV	0.301	0.611	.007	18	view →
OV	OS	Median	III,IV	0.796	0.863	.018	16	view →
READ	OS	Tertile	II,III,IV	1.000	0.825	.017	16	view →
LGG	DFS	Median	All	0.773	0.863	.002	16	view →
ACC	DFS	Quartile	All	0.880	0.303	.009	15	view →
ESCA	OS	Quartile	All	0.427	1.000	.033	14	view →
DLBC	DFS	Tertile	III,IV	0.130	0.684	.027	10	view →
LUSC	DFS	Quartile	III,IV	0.365	0.917	.022	8	view →
CESC	DFS	Quartile	III,IV	0.195	0.761	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0007039–KIRP (OS)

Open the KIRP breakdown →