Endoplasmic reticulum organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM11, INKA1, and SFRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum organization activity versus ADAM11 in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADAM11 →	-0.544	-0.281	<.001	<.001	3	5
CCRCC	INKA1 →	-0.564	-0.198	<.001	<.001	3	4
UCEC	SFRP1 →	-1.515	-0.180	<.001	.004	3	4
UCEC	AVPI1 →	-1.659	-0.217	<.001	<.001	3	4
UCEC	SOSTDC1 →	-1.249	-0.271	.001	.001	3	4
UCEC	FAM110D →	-0.922	-0.251	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007029 vs ADAM11 — BRCA

Explore this scatter interactively →