Endoplasmic reticulum organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SURF4, TMED9, and LRPAP1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum organization activity versus SURF4 in BLOOD_Myeloma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SURF4 →	+1.088	+0.104	<.001	.001	3	16
BONE	TMED9 →	+1.165	+0.068	<.001	<.001	3	15
BONE	LRPAP1 →	+1.245	+0.097	<.001	<.001	3	15
BONE	TMED7 →	+1.116	+0.077	<.001	<.001	3	14
BREAST	TOR1B →	+0.804	+0.062	<.001	<.001	3	14
BONE	FNDC3B →	+1.658	+0.074	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007029 vs SURF4 — BLOOD_Myeloma

Explore this scatter interactively →