Microtubule nucleation

Across TCGA patient cohorts, RNA activity of the Microtubule nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H, SSRP1, and MED8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule nucleation activity versus SUPT16H in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SUPT16H →	+0.316	+0.073	<.001	.001	3	7
UCEC	SSRP1 →	+0.340	+0.057	<.001	.001	3	6
UCEC	MED8 →	+0.146	+0.049	.001	.002	3	6
LSCC	IPO9 →	+0.329	+0.035	<.001	.002	3	6
LUAD	KCTD14 →	-0.493	-0.028	.004	.006	3	6
HNSC	MAN2A1 →	-0.341	-0.066	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007020 vs SUPT16H — HNSC

Explore this scatter interactively →