Microtubule nucleation

Across TCGA patient cohorts, RNA activity of the Microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMFG, FAM72D, and MOCS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule nucleation activity versus GMFG in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMFG →	-0.482	-0.669	.009	.001	3	5
GBM	FAM72D →	+0.247	+0.140	.008	.007	3	4
LSCC	MOCS1 →	-0.398	-0.538	.007	.001	3	4
LUAD	S1PR4 →	-0.419	-0.393	<.001	.005	3	4
LSCC	NLRP3 →	-0.551	-0.633	<.001	<.001	3	4
LSCC	CD6 →	-0.511	-0.565	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007020 vs GMFG — LSCC

Explore this scatter interactively →