Microtubule depolymerization

Across TCGA patient cohorts, RNA activity of the Microtubule depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S614, SMC4, and SPC24, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule depolymerization activity versus MAP1B_S614 in LSCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S614 →	+1.789	+0.057	<.001	<.001	3	8
LUAD	SMC4 →	+0.569	+0.071	<.001	<.001	3	8
GBM	SPC24 →	+0.635	+0.061	<.001	<.001	3	7
LUAD	TOP2A_S1247 →	+1.278	+0.064	<.001	<.001	3	7
LUAD	ECT2_T359 →	+1.331	+0.071	<.001	<.001	3	7
LSCC	IPO9 →	+0.246	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007019 vs MAP1B_S614 — LSCC

Explore this scatter interactively →