Response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBR5, CLIC2, and S100B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to osmotic stress activity versus UBR5 in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBR5 →	-0.206	-0.034	.003	.007	3	7
LSCC	CLIC2 →	+0.441	+0.043	<.001	<.001	3	7
OV	S100B →	+1.086	+0.050	<.001	<.001	3	6
GBM	SH3BGRL3 →	+0.324	+0.077	<.001	<.001	3	6
OV	SNRPD2 →	-0.389	-0.049	<.001	<.001	3	6
GBM	STAT5A →	+0.344	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006970 vs UBR5 — LSCC

Explore this scatter interactively →