Response to osmotic stress

Across TCGA pan-cancer cohorts, RNA activity of the Response to osmotic stress pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 82 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Response to osmotic stress pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and ESCA, show the opposite pattern, with higher activity associated with better survival.

MESO, SKCM, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.178	0.794	.001	41	view →
SKCM	OS	Tertile	All	0.827	0.687	<.001	37	view →
ESCA	DFS	Quartile	III,IV	0.711	0.279	.006	33	view →
LGG	DFS	Quartile	All	0.603	0.815	<.001	33	view →
READ	OS	Tertile	III,IV	1.000	0.254	<.001	23	view →
OV	OS	Median	All	0.645	0.724	.013	20	view →
THCA	DFS	Quartile	IV	0.620	1.000	.002	20	view →
STAD	DFS	Quartile	All	0.550	0.789	.019	15	view →
UVM	DFS	Median	III,IV	0.356	0.672	.009	14	view →
BRCA	DFS	Median	III,IV	0.595	0.369	.009	12	view →
LIHC	OS	Median	III,IV	0.599	0.204	.001	11	view →
ACC	OS	Tertile	All	0.975	0.814	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0006970–MESO (OS)

Open the MESO breakdown →