Golgi to plasma membrane transport

Across TCGA cell cohorts, RNA activity of the Golgi to plasma membrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf95, VASH2, and NHSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C10orf95 grouped by Golgi to plasma membrane transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C10orf95 →	+0.742	+0.178	.002	<.001	3	4
BLOOD_Leukemia	VASH2 →	+1.504	+0.885	<.001	.002	3	4
BLOOD_Leukemia	NHSL1 →	+1.469	+1.140	.001	.004	3	3
SKIN	TACR2 →	-0.462	-0.752	<.001	<.001	3	3
LARGE_INTESTINE	ZEB1 →	-1.094	-0.467	.002	.009	3	3
UPPER_AERODIGESTIVE_TRACT	TMPRSS13 →	+1.908	+0.174	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C10orf95 by Golgi to plasma membrane transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →