"Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"

Across TCGA patient cohorts, RNA activity of the "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OGN, OLFML1, and GPX3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" activity versus OGN in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OGN →	+0.987	+0.038	<.001	<.001	3	8
CCRCC	OLFML1 →	+1.088	+0.056	<.001	<.001	3	8
BRCA	GPX3 →	+0.400	+0.022	.002	.001	3	8
BRCA	LRP1 →	+0.548	+0.040	<.001	<.001	3	7
BRCA	YME1L1 →	-0.346	-0.034	<.001	<.001	3	7
PDAC	JPT1_S131 →	-0.731	-0.036	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006890 vs OGN — CCRCC

Explore this scatter interactively →