"Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"

Across TCGA pan-cancer cohorts, RNA activity of the "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 52 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher "Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.552	0.710	<.001	102	view →
UVM	DFS	Tertile	II,III,IV	0.292	0.723	.002	61	view →
UCS	DFS	Median	II,III,IV	0.633	0.173	<.001	52	view →
LGG	DFS	Median	All	0.632	0.803	<.001	44	view →
HNSC	DFS	Quartile	III,IV	0.408	0.261	.006	30	view →
SKCM	OS	Quartile	All	0.419	0.232	<.001	27	view →
KIRP	DFS	Median	All	0.471	0.696	.010	22	view →
UCEC	OS	Median	All	0.897	0.946	.002	20	view →
ESCA	OS	Median	III,IV	0.633	0.334	.011	17	view →
THCA	OS	Quartile	II,III,IV	0.929	0.983	.007	17	view →
DLBC	OS	Tertile	IV	0.147	1.000	.045	9	view →
MESO	OS	Tertile	IV	0.824	0.315	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0006890–KIRC (DFS)

Open the KIRC breakdown →