Xenobiotic transmembrane transport

Across TCGA cell cohorts, RNA activity of the Xenobiotic transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UQCR11, TLN1, and ZDHHC16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UQCR11 grouped by Xenobiotic transmembrane transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UQCR11 →	-0.540	-0.834	.001	<.001	3	3
CNS	TLN1 →	-1.082	-0.945	.007	.002	3	3
CNS	ZDHHC16 →	-0.627	-1.063	.005	<.001	3	3
CNS	TDRP →	+1.391	+1.000	<.001	<.001	3	3
CNS	H1-2 →	+0.893	+0.746	.008	.001	3	3
SOFT_TISSUE	MPG →	-0.738	-1.256	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UQCR11 by Xenobiotic transmembrane transport activity — CNS

Explore this box plot interactively →