Mitochondrial calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Mitochondrial calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACVR2A, ZNF134, and SRSF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion transmembrane transport activity versus ACVR2A in PDAC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ACVR2A →	-0.364	-0.147	<.001	<.001	3	5
CCRCC	ZNF134 →	-0.341	-0.143	.001	.002	3	5
GBM	SRSF11 →	-0.329	-0.148	.005	.004	3	5
LUAD	STAR →	-0.155	-0.129	.008	.002	3	5
PDAC	RNU6-484P →	-0.435	-0.132	.001	.001	3	5
PDAC	SNX5 →	-0.307	-0.134	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006851 vs ACVR2A — PDAC

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