Neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTAP, PLS3, and RFC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter transport activity versus CRTAP in CCRCC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRTAP →	-0.272	-0.537	.005	.002	3	4
UCEC	PLS3 →	-0.912	-0.381	<.001	.004	3	4
BRCA	RFC4 →	-0.515	-0.477	.003	.005	3	4
OV	IFI27L1 →	-0.585	-0.164	<.001	<.001	3	3
OV	RBM4B →	-0.317	-0.196	.001	<.001	3	3
OV	IYD →	+0.063	+0.160	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006836 vs CRTAP — CCRCC

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