Neurotransmitter transport

Across TCGA pan-cancer cohorts, RNA activity of the Neurotransmitter transport pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 208 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Neurotransmitter transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, COAD, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	1.000	0.800	.003	50	view →
COAD	DFS	Tertile	II,III,IV	0.508	0.757	.003	39	view →
MESO	OS	Median	IV	0.281	0.803	.001	36	view →
READ	OS	Tertile	II,III,IV	0.791	0.927	.008	31	view →
UCS	OS	Median	IV	0.276	0.749	.005	30	view →
ACC	DFS	Tertile	III,IV	0.089	0.592	.002	26	view →
BRCA	DFS	Quartile	III,IV	0.932	0.769	.001	25	view →
STAD	DFS	Tertile	II,III,IV	0.453	0.582	.017	22	view →
LGG	DFS	Median	All	0.892	0.788	<.001	21	view →
CHOL	OS	Quartile	All	0.297	1.000	.027	18	view →
LUAD	DFS	Tertile	IV	0.342	0.882	.008	18	view →
THCA	DFS	Quartile	IV	0.343	0.912	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0006836–KIRP (DFS)

Open the KIRP breakdown →