Isoprenoid metabolic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMAIP1, MBLAC1, and ATP5F1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid metabolic process activity versus PMAIP1 in BLOOD_Lymphoma (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PMAIP1 →	-1.539	-0.221	.009	.002	3	4
PANCREAS	MBLAC1 →	+0.661	+0.194	.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP5F1A →	+0.778	+0.200	<.001	<.001	3	4
PANCREAS	TRMT1 →	+0.974	+0.151	<.001	.006	3	3
PANCREAS	TMEM97 →	+1.627	+0.175	.003	<.001	2	4
PANCREAS	GAR1 →	+0.526	+0.202	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006720 vs PMAIP1 — BLOOD_Lymphoma

Explore this scatter interactively →