Cholesterol catabolic process

Across TCGA patient cohorts, RNA activity of the Cholesterol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3H, PLK3, and SCARF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol catabolic process activity versus APOBEC3H in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APOBEC3H →	+0.433	+0.158	<.001	.002	3	5
BRCA	PLK3 →	+0.578	+0.349	.003	<.001	2	6
LSCC	SCARF1 →	+0.506	+0.209	<.001	.004	3	5
GBM	S1PR1 →	+0.547	+0.128	.001	<.001	3	5
LSCC	PILRA →	+0.502	+0.242	<.001	<.001	3	5
LUAD	MCL1 →	+0.352	+0.339	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006707 vs APOBEC3H — LSCC

Explore this scatter interactively →