Cholesterol catabolic process

Across TCGA cell cohorts, RNA activity of the Cholesterol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE4, TAX1BP3, and PIGT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLE4 grouped by Cholesterol catabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	POLE4 →	-1.552	-1.973	.006	<.001	3	4
BONE	TAX1BP3 →	-1.570	-2.142	.001	<.001	3	4
BLOOD_Myeloma	PIGT →	-1.094	-1.781	.007	.006	3	4
SOFT_TISSUE	CAPG →	-4.695	-1.475	.001	.001	3	4
SOFT_TISSUE	TRAM2 →	-2.020	-1.351	.002	.001	3	4
BREAST	MRGBP →	-0.810	-0.889	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLE4 by Cholesterol catabolic process activity — BONE

Explore this box plot interactively →