Cholesterol catabolic process

Across TCGA cell cohorts, RNA activity of the Cholesterol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLCD3B, BMP7, and ZNF207, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol catabolic process activity versus TLCD3B in CNS (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TLCD3B →	+0.591	+2.271	.006	<.001	2	2
CNS	BMP7 →	+3.498	+2.271	.003	<.001	2	1
CNS	ZNF207 →	+0.171	+2.271	.005	<.001	2	1
CNS	MRPS31 →	+0.341	+2.271	.003	<.001	2	1
CNS	RHBDL1 →	+1.070	+2.271	.008	<.001	2	1
CNS	RSPH6A →	+0.033	+2.271	.004	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006707 vs TLCD3B — CNS

Explore this scatter interactively →